Synthesis of T-Pentyl Chloride Essay - 954 Words

Exp 23 B Synthesis of t-Pentyl Chloride 11-8-12 Purpose: The sysnthesis of t-Pentyl Chloride from alcohol. Procedure: Preparation of t-Pentyl Chloride. In a 125-mL separatory funnel, place 10.0 mL of t-pentyl alcohol (2-methyl-2-butanol, MW _ 88.2, d _ 0.805 g/mL) and 25 mL of concentrated hydrochloric acid (d _ 1.18 g/mL). Do not stopper the funnel. Gently swirl the mixture in the separatory funnel for about 1 minute. After this period of swirling, stopper the separatory funnel and carefully invert it. Without shaking the separatory funnel, immediately open the stopcock to release the pressure. Close the stopcock, shake the funnel several times, and again release the pressure through the stopcock (see Technique 12, Section†¦show more content†¦Wash (swirl and shake) the organic layer with one 10-mL portion of water and again drain the lower aqueous layer. Transfer the organic layer to a small, dry Erlenmeyer flask by pouring it from the top of the separatory funnel. Dry the crude t-pentyl chloride over 1.01 g of anhydrous calcium chloride until it is clear (see Technique 12, Section 12.9) . Swirl the alkyl halide with the drying agent to aid the drying. Distillation. Transfer the clear liquid to a dry 25-mL round-bottom flask using a Pasteur pipet. Add a boiling stone and distill the crude t-pentyl chloride in a dry apparatus. Collect the pure t-pentyl chloride in a receiver cooled in ice. Collect the material that boils between 78 °C and 84 °C. Weigh the product and calculate the percentage yield. Results | Weight | Empty Erlenmeyer flask | 39.23 g | Flask with collected t-pentyl chloride | 46.61 | Discussion First thing we did in this lab was to add HCl to the t-pentyl alcohol. We did this because by adding the HCl, we are creating what we wanted, t-pentyl chloride. Then, due to the difference in density, layers will form. The top layer and less dense is the organic layer, the t-pentyl chloride and the bottom layer is the aqueous layer. The purpose of shaking vigourously is to make sure that the 2 liquids mix properly, giving us the desired product t-pentyl chloride. Then we wash the organic layer with water. T-pentyl chloride is insoluble in water, so it wont beShow MoreRelatedNucleophilic Substitution: Synthesis of N-Butyl Bromide and T-Pentyl Chloride1608 Words   |  7 PagesNucleophilic Substitution | Synthesis of n-Butyl Bromide and t-Pentyl Chloride | | Jessica | [Pick the date] | Abstract The synthesis of the alkyl halide n-Butyl Bromide from alcohol is the foundation for the experiment. During the isolation of the n-butyl bromide, the crude product is washed with sulfuric acid, water, and sodium bicarbonate to remove any remaining acid or n-butyl alcohol. The primary alkyl halide halide n-butyl bromide is prepared by allowing n-butyl alcohol to react withRead MoreT Pentyl Chloride Lab Report Essay1028 Words   |  5 PagesSynthesis of t-Pentyl Chloride Introduction: Using SN1 reaction mechanism with hydrochloric acid, t-Pentyl alcohol was converted to t-Pentyl chloride in an acid catalyzed reaction. The reaction took place in a separatory funnel designed to separate immiscible liquids. The crude product was extracted by transferring a solute from one solvent to another. The process of washing the solutions by phase transfer was used in order to remove impurities from the main solvent layer. Finally, the crudeRead MoreDual ACC1 / ACC2 Inhibition9209 Words   |  37 Pagesselected for a SAR study of the effects of modifying the 3,4-pyrazole-fused moiety. Herein it was found that decreasing the bulk of the substituent at N-2 atom of the pyrazole ring (with respect to t-Bu group) similarly decreased ACC1/ACC2 inhibition. Increasing the bulkiness of this group (tert-pentyl) improved the IC50 values for both ACC1 and ACC2, but also resulted in an increase in HLM by a factor of 4, which outweighed the small inhibitory advantage. Introducing substitution at the N-1